VOL. 1, No. 2 / 3, July 2004

C.A.B. Clemetson [2004] Med Hypotheses Res 1: 121-129.

Capillary Fragility as a Cause of Subdural
Hemorrhage in Infants

C. Alan B. Clemetson

Department of Obstetrics and Gynecology, Tulane University School of Medicine, New
Orleans, Louisiana 70112, USA

Abstract.  Malnutrition, excessive vomiting, surgery, or infection can cause a pregnant
woman to develop a profound vitamin C deficiency and an excessive blood histamine
level, leading to capillary and venular fragility. Sleep lack and other stresses in the mother
can further elevate her blood histamine level and affect the unborn child, thus weakening
the retinal capillaries and the bridging veins between the brain and the dura mater.
Subdural hemorrhages in the infant have now been identified by ultrasound examination
before birth and even before labor. Vaccines and toxoids have been shown to increase the
blood histamine level of guinea pigs. We need to establish the blood histamine and
ascorbic acid levels of human subjects before and after single and multiple inoculations.
Undoubtedly, the histamine level will increase more in those having low ascorbic acid
levels, and especially in those receiving multiple inoculations. Research is needed to
determine which inoculants cause the highest blood histamine level, or histaminemia, and
when it peaks.

*Address all correspondence to: Dr. C. Alan B. Clemetson, 5844 Fontainebleau Drive,
New Orleans, Louisiana 70125 (USA).
Telephone: (504) 866-1525; Email:

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