VOL. 1, No. 4, October 2004

N. Keklikoglu, et al. [2004] Med Hypotheses Res 1: 261-266.

Localization of c-Fos Oncoprotein in Renal Cortex in

Nurullah Keklikoglu*, Kamer Gokhan, Ilker Bolat and Sevtap Akinci

Istanbul University, Faculty of Dentistry, Department of Histology and Embryology,
Istanbul (N.K., I.B., S.A.) and Bogazici University, Medicosocial Center Dental Clinic,
Istanbul (K.G.)

Abstract.  It is known that the expression of the proto-oncogene c-fos is increased in
kidney tumors and in the relevant cells of the proliferative diseases of the glomeruli. The
aim of this study was to detect the areas that have a tendency for oncogenic transformation
and proliferation in renal cortex. For that purpose, oncoprotein c-Fos immunoreactivity (c-
Fos-ir) has been assessed in formalin-fixed, paraffin-embedded sections of mesangial cells
(MCs), squamous cells lining Bowman’s capsule (SCs), and distal and proximal tubular
cells (TCs) by immunohistochemichal methods. The highest level of c-Fos-ir positivity was
observed in MCs, and this was followed by SCs and TCs. Statistical comparisons showed
significant differences between each of the three groups with regard to c-Fos-ir (P < 0.01).  
The observation regarding the higher tendency for mitogenic and oncogenic transformation
in MCs and SCs compared to TCs in our study may provide a contribution to
pathogenicity studies exploring the oncogenic and cellular proliferation in renal cortex.

*Address all correspondence to: Dr. Nurullah Keklikoglu, Istanbul Universitesi,
Dishekimligi Fakultesi, Histoloji ve Embriyoloji BD, Capa, Istanbul, Turkey. E-Mail:

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