VOL. 2, No. 3, July 2005

K. Mizia-Stec, et al. [2005] Med Hypotheses Res 2: 469-479.

Ghrelin as a Potential Factor that Reduces Blood
Pressure during Weight Loss Treatment

Katarzyna Mizia-Stec, Magdalena Olszanecka-Glinianowicz, Barbara
Zahorska-Markiewicz and Zbigniew Gąsior

Department of Cardiology Silesian University of Medicine, Katowice, Poland (K.M.-S., Z.G.)
and Department of Pathophysiology Silesian University of Medicine, Katowice, Poland (M.O.
-G., B.Z.-M.)

Abstract. A close relation between obesity and hypertension has been reported in
epidemiological studies. The present paper presents data on ghrelin, a peptide whose
involvement in the regulation of appetite, metabolic processes, and cardiovascular system
seems to be of considerable importance in the pathophysiology of hypertension. By
sympathetic suppression, improvement of baroreflex control, and, probably, peripheral
vasodilatation, the peptide can exert positive hemodynamic action. Some other ghrelin-
related mechanisms such as antiinflammatory and antioxidant role, modulation of insulin-
resistance as well as contra-regulatory role in food intake are also significant. However,
ghrelin constitutes a part of a complex network; it both influences and is influenced by
several factors. All neurotransmitters – such as leptin, ghrelin, NPY, AGRP – might as well
participate in sympathetic and arterial pressure regulation.

*Address all correspondence to: Dr. Barbara Zahorska-Markiewicz, Department of
Pathophysiology, Silesian University of Medicine, Medyków Street 18, 40-752 Katowice,
Poland.  Phone/Fax: +48 32 25 26 091. E-Mail:

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