VOL. 2, No. 4, October 2005

A. G. Payne [2005] Med Hypotheses Res 2: 553-565.

Preventing Metastasis and Achieving Oncolysis in Solid
Tumors by Inhibiting Specific Metalloproteinases and
Manipulating Key Metabolic Pathways

Anthony G. Payne*

Abstract. Approximately 50% of solid tumors bear mutations to the p53 gene and
typically contain hypoxic microclusters. By artfully manipulating key metabolic anaerobic
biochemical pathways, it should be possible to increase lactate and block its excretion,
resulting in lethal reductions in intracellular pH. Compounds are advanced for
accomplishing this as well as helping eradicate non-hypoxic regions of tumors, based on
predecessor methods which results in long term remissions in persons with a host of solid
tumor malignancies. A number of measures are also introduced for inducing oncostasis and
preventing metastasis. Any remaining tumor mass can be treated using whatever standard
chemotherapeutic, radiotherapeutic, surgical or immunologic interventions or combinations
thereof are deemed most likely to result in oncolysis.

*Address all correspondence to: Dr. Anthony G. Payne, Steenblock Research
Institute, 1064 Calle Negocio #B, San Clemente, CA 92673 USA. Phone: 949-248-7034; Fax:
949-388-3441. E-mail:

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