VOL. 2, No. 4, October 2005

M. Budroni, et al. [2005] Med Hypotheses Res 2: 581-586.

Possible Association of Kaposi’s Sarcoma and Multiple
tumours: Epidemiological Evidence from the Cancer
Registry of North Sardinia

Mario Budroni*, Rosaria Cesaraccio, Antonio Cossu, Giuseppe
Palmieri, Massimiliano Oggiano, Amelia Sechi, Daniela Piras and
Francesco Tanda

Abstract. Background: The observation of multiple tumours is becoming more and
more frequent. The immune deficiency caused by infectious diseases, cancer and/or
pharmacological treatment may contribute to the onset of a second cancer. Some of the risks
may be due to the increased site-specific medical surveillance. Conversely, some associations
are difficult to be explained. Methods: Incidence of Kaposi’s sarcoma (KS) linked to or not
linked to the epidemic of acquired immunodeficiency syndrome (AIDS) was assessed in
North Sardinia. The presence of synchronous or asynchronous tumours was included into
the models for the definition of the relative risk. Results: The KS European adjusted rate was
found higher in males (3.9%) than in females (1.4%). Incidence of KS in Sardinia is slowly
decreasing despite both the spread of AIDS epidemic and the ageing of population (some
social changes may be responsible for this phenomenon). The relative risk of multiple
tumours in KS was higher compared to those observed in all the other tumours. Altogether,
a second primary malignancy was observed in 15/106 (14%) KS males and 3/45 (7%) KS
females. Among males, KS was increasing until 1997 before registering its trend inversion;
among females, KS incidence is still increasing. Conclusion: Our findings strongly indicate
that patients affected by Kaposi’s sarcoma present a risk for the occurrence of multiple

*Address all correspondence to: Dr. Mario Budroni, Centro Multizonale di
Osservazione Epidemiologica, Azienda Unità Sanitaria Locale 1, Via Tempio 5 - 07100
Sassari. Phone: 39-079-2062442. FAX: 39-079-2062445.

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