VOL. 3, No. 1, January 2006

M. Hofer and M. Pospíšil [2006] Med Hypotheses Res 3: 629-635.

Role of Adenosine Signaling in Hematopoiesis – A Short

Michal Hofer* and Milan Pospíšil

Abstract. Hitherto obtained data on the action of adenosine receptor signaling in the
control hematopoiesis are summarized and discussed. Four subtypes of adenosine membrane
receptors, designated as A1, A2A, A2B, and A3, are known to exist. Their pharmacologically
induced activation can be either non-selective, elicited through elevation of extracellular
adenosine levels, or by administration of synthetic adenosine analogs, more or less specific
for individual receptor subtypes. The data acquired mostly from in vivo experiments on mice
show evidence about an important role of adenosine receptor signaling in the hematopoietic
regulatory network. Non-selective activation of adenosine  receptors evoked  by combined
administration of dipyridamole, preventing the cellular uptake of adenosine, and adenosine
monophosphate, an adenosine prodrug, has been found to stimulate hematopoiesis in
normal mice, as well as in animals in which myelosuppression was induced by ionizing
radiation or cytotoxic drugs. Studies using synthetic adenosine analogs have shown that
activation of adenosine A3 receptors is responsible for this stimulation and has curative
effects. Directions for further research aimed at revealing exact mechanisms of adenosine
receptor signaling in hematopoiesis are briefly delineated.

*Address all correspondence to: Dr. Michal Hofer, Laboratory of Experimental
Hematology, Institute of Biophysics, Academy of Sciences of the Czech Republic,
Královopolská 135, CZ-612 65 Brno, Czech Republic.
Phone: +420-541517171. Fax: +420-541211293. E-mail:

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