VOL. 3, No. 2, April 2006

F. Ramirez, et al. [2006] Med Hypotheses Res 3: 679-686.

Umbilical Cord Stem Cell Therapy for Cerebral Palsy

Fernando Ramirez, David A. Steenblock, Anthony G. Payne* and
Lyn Darnall

International Spinal Cord Regeneration Center, Lloyd Building, Paseo Tijuana 406-Ste #203,
Segunda Piso, Zona Del Rio, Tijuana, Baja California, Mexico CP 22310 (F.R.), and
Steenblock Research Institute, 1064 Calle Negocio #B, San Clemente, CA 92673, USA
(D.A.S., A.G.P., L.D.)

Abstract. The authors hypothesize that stem/progenitor cells from umbilical cord
blood are safe and promising for various brain injuries and disorders. A six month pilot
study predicated on parental observations and completed questionnaires concerning the
responses of cerebral palsy-stricken children to treatment with umbilical cord stem cells was
launched during 2004. As part of this Mexican study, eight children (3–12 years of age)
diagnosed with cerebral palsy underwent transplants with 1.5 million stem/progenitor cells
(CD34+ and CD133+) that had been purified and expanded from the American Association
of Blood Banks (AABB)-certified human umbilical cord blood. According to parent tendered
observational reports, none of the children had graft versus host reactions. Eight out of eight
children showed some improvement in mobility and/or cognitive function. Six children
(75%) were rated as improving in muscle tone, hip movement, leg movement, rolling to the
side, balancing while sitting and balancing while standing by the end of the six month follow
up. Further research, correlating parent ratings with tomography studies and physical
therapy evaluations, seems warranted.

*Address all correspondence to: Dr. A. G. Payne, Steenblock Research Institute,
1064 Calle Negocio #B, San Clemente, CA 92673, USA.  Phone: (949) 248-7034. Fax: (949)
388-3441. E-Mail:

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