MEDICAL HYPOTHESES AND RESEARCH
VOL. 3, No. 3/4, October 2006



T. Isobe, et al. [2006] Med Hypotheses Res 3: 751-760.


Relationship between Serum Adiponectin Levels and
Metabolic Syndrome Diagnosed by Using the New
Criteria for Metabolic Syndrome for Japanese: The
Tanno and Sobetsu Study


Takeshi Isobe*, Shigeyuki Saitoh, Hirofumi Ohonishi and
Kazuaki Shimamoto

Second Department of Internal Medicine, Sapporo Medical University, School of Medicine,
S-1, W-16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan


Abstract. The aim of this review study is to determine the relationship between
adiponectin level and metabolic syndrome (MS), based on a new clinical definition made for
Japanese. A total of 1067 participants in mass-screening tests for residents of two rural
communities in Japan in 2002 and 2003 were selected after exclusion of patients undergoing
treatment for hypertension or diabetes. MS was defined on the basis of visceral fat
accumulation, which is defined as waist circumference (WC) 85 cm for males and > or = 90
cm for females, plus any two of the following three factors: 1. elevated triglyceride levels (>
or = 150 mg/dL) or specific treatment for this lipid abnormality and/or reduced high-density
lipoprotein (< 40 mg/dL) or specific treatment for this lipid abnormality; 2. elevated blood
pressure (BP; systolic BP > or = 130 and/or diastolic BP > or = 85 mmHg); 3. elevated fasting
plasma glucose (> or =110 mg/dL). In multiple regression analysis with adiponectin as a
dependent variable, the body mass index (BMI) and WC were selected as independent
variables, and so as the sex differences, age, and fasting plasma insulin levels. Furthermore,
adiponectin showed tighter, negative standardized regression coefficients with WC than with
BMI (0.268 versus 0.160). Adiponectin levels were significantly lower in subjects with
MS than in subjects without MS in both males and females, and were still significantly lower
after adjustment for age differences. Plasma levels of adiponectin, an adipocyte-derived
antiatherogenic protein, were low in subjects with MS diagnosed by the new criteria for
Japanese.

*Address all correspondence to: Dr. Takeshi Isobe, Second Department of Internal
Medicine, Sapporo Medical University, School of Medicine, S-1, W-16, Chuo-ku, Sapporo
060-8543, Japan. Telephone: +81-11-6112111 (ext. 3225). Fax: +81-11-6447958. E-Mail
address:
isobet@sapmed.ac.jp



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