VOL. 3, No. 3/4, October 2006

L. Raptis, et al. [2006] Med Hypotheses Res 3: 827-835.

Correlation of Histopathological Findings with Clinical
and Laboratory Features in Leukocytoclastic Vasculitis:
A Retrospective Study

Lampros Raptis*, Stella Stefanaki, Georgios Kurgias, Basiliki Baka,
Dimitrios Petrakis, Asimo Ntemou and Nikolaos Akritidis

Department of Internal Medicine (L.R., G.K., B.B., D.P., N.A.) and Department of
Pathology (S.S., A.N.), General Hospital ‘G Hatzikosta’, Ioannina, Greece

Abstract. Aim: To probe the correlation of histopathological findings with clinical and
laboratory features in leukocytoclastic vasculitis. Methods: Twelve patients with a mean age
57.5 years were participated in a 3-years retrospective study with early disease of
leukocytoclastic vasculitis. Complete blood count, biochemistry profile, a screening for
autoimmune disease and CT scan of chest and abdomen to exclude primary malignancy,
were performed in all patients. All patients had typically skin lesions over legs and/or lower
abdomen and a positive exposure to drugs or infections. A skin biopsy confirmed the
diagnosis of leukocytoclastic vasculitis. Results: Skin biopsy samples revealed the presence of
perivascular infiltration of polymorphonuclear leukocytes with formation of nuclear dust
(leukocytoclasis), extravasation of erythrocytes, and fibrinoid necrosis of the vessel walls.
Patients with early disease had general symptoms of fever, lyphadenopathy and arthralgia
and laboratory signs of inflammation such as elevation of erythrocyte sedimentation rate
and C-reactive protein. They were treated with prezolone 5 mg per day for 30 days with
progressive improvement of lesion. A follow up of six and twelve months’ duration was
performed in all patients. Conclusions: In our study drugs were the predominant cause of
leukocytoclastic vasculitis in 66.6%. Accompanying clinical and laboratory parameters may
significantly augment in orientation of differential diagnosis of leukocytoclastic vasculitis.

*Address all correspondence to: Dr. Lampros Raptis, Internal Medicine
Department, General Hospital ‘G Hatzikosta’, Makrygianni Avenue, 45500, Ioannina,
Greece. Telephone: +30-26510-70943. E-Mail:

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