MEDICAL HYPOTHESES AND RESEARCH
VOL. 4, No. 2, July 2008
L. M. Agius  Med. Hypotheses Res. 1: 63‒68.
Supra-cellular Malignant Transformation in Breast
Lawrence M. Agius*
Department of Pathology, St Luke’s Hospital Gwardamangia, University of Malta Medical
School, Msida Msd09, Malta, Europe
Abstract. Full evolution of new tissue and cellular traits in the acquisition of malignant
potentiality would be predetermined in terms of consequence and sequentiality of various
converging pathways that otherwise tend to developmentally differentiate and diverge.
Indeed, beyond simple identification of the various defined models in determining such
phenomena of immortalization as proliferative index and infiltrative front, one might further
realize pathways in the delineation of metastatic potentiality as pathobiology and
pathogenesis rather than as instituted etiologic factors. In the various redefined descriptions
of histomorphologic profiles and determinations of modeled replication as templates of
consequence, one might further identify regions of cellularity and supracellularity beyond the
developmental history of lesion predetermination. There would evolve templates of
predetermination as direct consequences of a series of pathophysiologic sequences that
further identify the bridging basis for cellular and tissue pathophysiology in terms of
metastatic potentiality of a given individual malignant neoplasm of the breast.
Correspondence: Dr. Lawrence M. Agius, Department of Pathology, St Luke’s Hospital
wardamangia, University of Malta Medical School, Msida Msd09, Malta, Europe. Tel: 356-
2145-1752. Fax: 356-2595-6372. E-Mail: Lawrence.Agius@um.edu.mt
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