MEDICAL HYPOTHESES AND RESEARCH
VOL. 5, No. 1/2, July 2009
J. Ai, et al.  Med. Hypotheses Res. 5: 93‒97.
A Possible Cell Therapy for Critical Limb Ischemia in
Women by Using Endometrial Adult Stem Cells
Jafar Ai*, Fatemeh Sadat Tabatabaei and Bagher Larijani
Department of Tissue engineering, Faculty of Advance Technology (J.A.), Department of
Dental Materials, Faculty of Dentistry (F.S.T.), and Endocrinology and Metabolism Research
Center, Tehran University of Medical Sciences, Tehran, Iran (B.L).
Abstract. Critical limb ischemia is manifested by pain at rest, nonhealing wounds and
gangrene. Approximately 20–45% of patients require amputation. Autologous bone marrow
therapy for lower limb ischemia appears to be a promising solution to the current lack of
treatments in patients ineligible for endovascular/surgical interventions. However, this is
limited by the need for anesthesia during the bone marrow extraction procedure, which is
dangerous in the lower limb ischemia population since numerous co-morbidities exist. We
hypothesized that endometrial stromal cells are more suitable candidates for lower limb
ischemia cell therapy in women.
* Correspondence: Dr. J. Ai, Department of Tissue engineering, Faculty of Advance
Technology, Tehran University of Medical Sciences, Tehran, Iran. Tel: +982166905717. Fax:
+982166581533. E-Mail: email@example.com