VOL. 5, No. 1/2, July 2009

L. M. Agius [2009] Med. Hypotheses Res. 5: 63‒69.

Biologic Correlates of Paraneoplasia and Preneoplasia in

Lawrence M. Agius*

Department Of Pathology, Mater Dei Hospital, Tal-Qroqq, Malta Europe

ABSTRACT. Dynamic evolution of injury to the mucosa of the stomach appears to
operate as inflammatory consequences, as delineated by regional distribution in the antrum
or gastric corpus in particular. Paraneoplasia and preneoplasia appear representations of
such distribution pattern, and as parametric correlates of onset and progression of a
transformation process emanating from surface epithelium and crypt stem cells. Biology of
the derived characterization of the mucosal inflammation is represented by multiple
superimpositions of various inflammatory states ranging from acute to chronic gastritis, and
also gastric mucosal atrophy. In terms that are contributory towards a concept of realized
consequence of an inflammatory infiltrate arising within the lamina propria, it might further
appear that the distribution patterns of metaplasia are simply representative of dynamics of
an onset process in inflammatory involvement of the mucosa. It is only with reference to
such consequences as parallel and subsequent development of cell injury that the gastritis
proves a phenomenon of persistence rather than simply of intensity of the reactive changes
affecting both a primary surface epithelial cell pool and the stem cells that populate the
glandular crypts of the gastric mucosa.

* Correspondence: Dr. Lawrence M. Agius, 27 “Ballarat” Guzeppe Caruana Street,
Tal-Virtu Rabat Rbt09, Malta Europe. Tel: 356-2145-1752 or 356-2545-6444. Fax: 356-
216449. E-mail: or