MEDICAL HYPOTHESES AND RESEARCH
VOL. 6, No. 1/2, July 2010
L. M. Agius  Med. Hypotheses Res. 6: 43-50.
Uncoupled Endothelial/Cardiomyocyte Patterns of
Dysfunctionality in Clinical Heart Failure
Lawrence M. Agius*
Department of Pathology, Mater Dei Hospital, Tal-Qroqq, University of Malta Medical
School, Msida, Malta, Europe
Abstract. Essential coupling and uncoupling of ventricular cardiac contractility in terms
of the realized interaction of right with left ventricular function would implicate cyclical
action and reaction patterns of development of heart muscle physiology and
pathophysiology. In terms beyond simple enumeration of interacting parameters, there
evolves an individual cardiomyocyte inter-relationship with supplying endothelial cell bed
comprising endocardial sensor mechanisms and a centralized pulmonary vascular
endothelium. It is in view of realized consequence to such cyclical contractility of integral
muscle mass of individual ventricles that the development and refashioning of heart
physiology encompasses further evolutionary patterning based on remodelling of action and
reaction phenomena. In final analysis, the restructuring of both functional and morphologic
phenotypes of ventricular muscle mass implicates a progression of ischemic events based on
parametric derivation of essential blood-heart barrier functionality or dysfunctionality.
Correspondence: Dr. A. M. Agius, Department of Pathology, Mater Dei Hospital,
Tal-Qroqq, University of Malta Medical School, Msida Malta, Europe. Tel: 356-25456444.
Fax: 356-25456449. E-Mail: firstname.lastname@example.org