VOL. 6, No. 1/2, July 2010

M. Hosseini, et al. [2010] Med. Hypotheses Res. 6: 51-59.

Potential Preventions and Treatments of Alzheimer’s
Disease: A Pathophysiologic Approach

Motahharsadat Hosseini, Sayed Shahabuddin Hoseini and
Saeed Shoar*

Isfahan University of Medical Sciences (M.H.); Department of Pediatric
Hematology/Oncology and Blood Stem Cell Transplantation, Hannover Medical School,
Hannover, Germany (S.S.H.); Developmental Association for Clinical Study (DACS), Tehran
University of Medical Sciences, Tehran, Iran (S.S.); and Student Scientific Research Center
(SSRC), Tehran University of Medical Sciences, Tehran, Iran (S.S.)

Abstract. Alzheimer's disease (AD) is the main cause of dementia in elderly worldwide. An
important initial step in controlling this disorder includes the experimental verification of the
pathophysiologic and mechanistic models. Here we reviewed previous pathophysiologic
findings concerning vascular and inflammatory mechanisms, and also proposed a model that
may help understand neuronal cell death. According to the suggested model, some potential
therapies are discussed. It is suggested that sorafenib, sunitinib maleate, rosiglitazone,
antagonists of TNF (adalimumab, etanercept, infliximab, and thalidomide), anakinra, and
some other drugs may be beneficial for the prevention or treatment of Alzheimer's disease.

Correspondence: Dr. Saeed Shoar, Developmental Association for Clinical Study, Student
Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. Tel: +98-
913-362-0932. Fax: +98-361-5426532. E-Mails:;