MEDICAL HYPOTHESES AND RESEARCH
VOL. 7, No. 1/2, December 2011
Y. Jin, et al.  Med. Hypotheses Res. 7: 43-47.
Hydrogen May Be Used as a Treatment for Stress-
Induced Gastric Ulceration
Yichao Jin, Xiaochen Qiu, Yu Sun, Guofeng Huang, Xuejun Sun and
The Burn Center, Changhai Hospital, Second Military Medical University, Shanghai 200433,
China (Y.J., X.Q., Y.S., G.H., Z.F.X.); Department of Diving Medicine, Second Military
Medical University, Shanghai 200433, China (X.S.); and Department of pathology, Kunming
medical college, Kunming 650031, China (Y.J.)
Abstract. Recently, it has been shown that hydrogen, a potent hydroxyl radical (•OH)
scavenger, can effectively protect animals against reactive oxygen species-induced tissue
damage. Stress-associated ulceration is a type of diffuse lesions of the mucosal layer of the
stomach and sometimes also of the duodenum, and it frequently occurs as a result of major
stressful events. Direct evidence has been presented to show that •OH is one of the major
causative factors of stress-induced gastric ulceration. Treatment with a potent antioxidant or
•OH scavenger can decrease stress-induced gastric mucosal damage. In a similar manner, it is
suggested here that that hydrogen may be used as an effective means to counteract stress-
induced •OH and thus provide protection against stress-induced gastric ulceration.
§ These two authors contributed almost equally to this work.
Correspondence: Dr. Zhao-Fan Xia, the Burn center, Changhai Hospital, Second Military
Medical University, Shanghai 200433, China. TEL: +86-21-81873471. FAX: +86-21-65589829.