MEDICAL HYPOTHESES AND RESEARCH
VOL. 7, No. 1/2, December 2011



Y. Jin, et al. [2011] Med. Hypotheses Res. 7: 43-47.

Hydrogen May Be Used as a Treatment for Stress-
Induced Gastric Ulceration

Yichao Jin, Xiaochen Qiu, Yu Sun, Guofeng Huang, Xuejun Sun and
Zhao-Fan Xia*

The Burn Center, Changhai Hospital, Second Military Medical University, Shanghai 200433,
China (Y.J., X.Q., Y.S., G.H., Z.F.X.); Department of Diving Medicine, Second Military
Medical University, Shanghai 200433, China (X.S.); and Department of pathology, Kunming
medical college, Kunming 650031, China (Y.J.)

Abstract. Recently, it has been shown that hydrogen, a potent hydroxyl radical (•OH)
scavenger, can effectively protect animals against reactive oxygen species-induced tissue
damage. Stress-associated ulceration is a type of diffuse lesions of the mucosal layer of the
stomach and sometimes also of the duodenum, and it frequently occurs as a result of major
stressful events. Direct evidence has been presented to show that •OH is one of the major
causative factors of stress-induced gastric ulceration. Treatment with a potent antioxidant or
•OH scavenger can decrease stress-induced gastric mucosal damage. In a similar manner, it is
suggested here that that hydrogen may be used as an effective means to counteract stress-
induced •OH and thus provide protection against stress-induced gastric ulceration.

§ These two authors contributed almost equally to this work.
Correspondence: Dr. Zhao-Fan Xia, the Burn center, Changhai Hospital, Second Military
Medical University, Shanghai 200433, China. TEL: +86-21-81873471. FAX: +86-21-65589829.
E-MAIL:
qiuxiaochen1987@gmail.com

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