MEDICAL HYPOTHESES AND RESEARCH
VOL. 8, No. 1/2, December 2012


L. M. Agius* 2012] Med. Hypotheses Res. 8: 57-63.

Retargeting of Immature Oligodendrocytes Precipitates
the Multiple Sclerosis Plaque

Lawrence M. Agius*

Department of Pathology, Mater Dei Hospital, Tal-Qroqq, University of Malta Medical
School, Msida, Malta, Europe


Abstract. Disease developmental injury of oligodendrocytes compromises the
maturational potential of these cells as they proliferate and attempt to reconstitute the myelin
sheath of parent axons in multiple sclerosis. Involvement of injury is a sequential and also
non-sequential form of activity that participates in the emergence of multiple forms of
dynamic turnover within the multiple sclerosis plaque. The complex of
inflammatory/demyelination earmarks such events in terms of ongoing injury to the
oligodendrocyte in the first instance. The perivascular space remodelling invokes a gliotic
response and a redistribution of injury to multiple other cellular components within
encompassed confines of both neuronal axon and immune response. Macrophages attempt to
reconstitute the microenvironment of the multiple sclerosis plaque within systems of
redefined constitutional identity. Gliosis is a persistent overlapping series of systems in
reconstruction of a perivascular space that proves irreversible inducer for further
participation by systemic events in expansion and progression of the individual multiple
sclerosis plaque.         


* Correspondence: Dr. L. M. Agius, Department of Pathology, Mater Dei Hospital,
Tal-Qroqq, Univesity of Malta Medical School, Msida, Malta, Europe. PHONE:
356-2545-6444. FAX: 356-2545-6449.
E-MAIL:
lawrence.agius@um.edu.mt


PDF