VOL. 9, No. 1/2, December 2014

W. Allaerts [2014] Med. Hypotheses Res. 9: 1-15.

Annotation Grids for Cell Lineage and Tumor
Metastasis: II. Defining the Architecture for Multiscale
Probabilistic and Deterministic Models

Abstract. The versatility of cell groups, either by malignant transformation or controlled
reprogramming, forms an important challenge to modeling studies for cellular development.
Especially in tumor metastasis, multiscale modeling benefits from the combination of
probabilistic and deterministic aspects of cellular behavior. The theoretical notions used in
multiscale modeling are summarized, starting from a cell-free finite state projection model to
which methods for cell-based cell modeling are added. From recent studies addressing the
notions of cell developmental ‘roadmaps’ and cell-state ‘landscapes’, a comprehensive
architecture is proposed for the study of cell-state modeling.

Correspondence:  Dr. Wilfried Allaerts, Biological Publishing, P. O. Box 104, NL-7440
AC Nijverdal, The Netherlands.  E-Mail: